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Much of the show focuses on science, particularly physics. The four main male characters are employed at Caltech and have science-related occupations. The characters frequently banter about scientific theories or news (notably around the start of the show), and make science-related jokes.
Science has also interfered with the characters' romantic lives. Leslie broke up with Leonard when he sided with Sheldon in his support for string theory rather than her support for loop quantum gravity.[48] When Leonard joined Sheldon, Raj, and Howard on a three-month Arctic research trip, it separated Leonard and Penny at a time their relationship was budding. When Bernadette took an interest in Leonard's work, it made both Penny and Howard jealous and resulted in Howard confronting Leonard, and Penny asking Sheldon to teach her physics.[49] Sheldon and Amy also briefly ended their relationship after an argument over which of their fields was superior to the other's.[50]
David Saltzberg, who has a Ph.D. in physics, has served as science consultant for the show for five seasons. While Salzberg knows physics, he sometimes needs assistance from Mayim Bialik, who has a Ph.D. in neuroscience. Salzberg sees early versions of scripts which need scientific information added to them, and he also points out where the writers, despite their knowledge of science, have made a mistake. He is usually not needed in a taping unless a lot of science, and especially the whiteboard, is involved
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